Combining CBD with ibuprofen according to research is not a bad idea. Studies show that both compounds can be mixed without the risk of adverse effects. It depends on the user’s tolerance and sensitivity to both drugs. Not all NSAIDs can be combined with CBD. Most especially naproxen and celecoxib; mixing either of these with CBD can be severe. To be safe, make sure you consult your doctor before mixing ibuprofen and CBD. This is because while there has been no proven interaction between both drugs, your body could have a personal reaction.